No point in clicking the spoiler alert.  You can find out everything there is to know about this book from the solicit.  Punisher gets nabbed.  Punisher gets injected with deadly toxin.  Punisher has to kill certain individual if he ever wants to learn the whereabouts of antidote.  Pretty basic.  There were a couple other non-related murders but I won't spoil that part for you.
I don't read Punisher very often.  Actually, other than the Punisher #1 (eighth volume) I pulled last week, I haven't read any Punisher books since the 1990s.  Everybody always tells me I should check out the beginning of this series from back when Garth Ennis was writing.  Hmmmm...
Maybe I will if I ever finish reading all those damn Preacher trades!!