Spider-Man’s parade of all-star team-ups continues as he fights side-by-side with Nick Fury, Black Widow, Hawkeye, Hulk, the Guardians of the Galaxy, Dr. Strange, Ms. Marvel, Black Panther, Nightcrawler, Beast, Ghost Rider, Howard the Duck, X-51, Luke Cage, Iron Fist and more – against a non-stop onslaught of deadly foes including the Silver Dagger, the Griffin, Boomerang, the Maggia, Arcade, Killer Shrike, Mr. Fear, Tatterdemalion, the Owl and Nightshade! And in a special multi-part epic, Spider-Man and S.H.I.E.L.D. must race against time to save the president from death at the hands of Viper and the Silver Samurai!